Reduction in mitochondrial membrane peroxidizability index…
613
Reduction in mitochondrial membrane peroxidizability index
and protein lipoxidation levels in the rat heart after ß-‐
adrenergic receptor signaling interruption with the ß-‐blocker
atenolol
Alexia Gómez
1
, Inés Sánchez Román
1
, José Gómez
1
, Alba Naudi
2
, Charumati
Pushparaj
2
, Manuel Portero-‐Otin
2
, Mónica López-‐Torres
1
, Reinald Pamplona
2
,
Gustavo Barja
*
1
1
Department of Animal Physiology II, Faculty of Biological Sciences, Complutense University, Madrid
28040, Spain
2
Department of Experimental Medicine, Faculty of Medicine, University of Lleida-‐IRBLleida,
Lleida 25008, Spain.
* Corresponding author: Prof. G. Barja. Department of Animal Physiology II, Faculty of Biological
Sciences, Complutense University, c/Antonio Novais nº 2, Madrid 28040, Spain. e-‐mail:
Recibido el 18 de junio de 2013
An. Real Acad. Farm. Vol 79, Nº 4 (2013), pag. 613-‐633
ABSTRACT
A new mammalian longevity model based on ß-‐adrenergic signaling interruption
at the level of adenylyl cyclase has reported decreased bone and heart aging and
mean and maximum longevity increases in AC5KO mice (1). We decided to mimic
this model in male Wistar rats treated with the ß-‐blocker atenolol in the drinking
water and to check if an oxidative stress decrease could be involved. Atenolol
treatment did not modify heart mitROS generation rate and mitDNA oxidative
damage but significantly decreased global peroxidizability index of mitochondrial
membranes, as well as protein lipoxidation, probably mediated by changes in
elongases and desaturases activities.
Keywords:
Oxidative stress; β-‐blocker; Lipid damage.
RESUMEN
Reducción en el índice de peroxidizabilidad de la membrana mitocondrial y niveles de
lipoxidación proteícos en el corazón de la rata después de la interrupción de la
señalización del receptor betaadrenérgico con el betabloqueante atenolol
Un nuevo modelo de longevidad en mamíferos basado en la interrupción de la vía
de señalización beta-‐adrenérgica a nivel de la adenilato ciclasa ha revelado una
ARTÍCULO
