J. R. Lacadena y F. Mayor Menéndez
150
28. Kobilka, B. K.; Kobilka, T. S. et al. Chimeric alpha 2-‐,beta 2-‐adrenergic receptors: delineation
of domains involved in effector coupling and ligand binding specificity. Science 240, 1310-‐
1316 (1988).
29. Pitcher, J.A; Freedman, N.J.; Lefkowitz, R.J. G protein-‐coupled receptor kinases. Annu Rev
Biochem 67, 653-‐792 (1998).
30. Lefkowitz ,R.J.; Shenoy, S.K. Transduction of receptor signals by beta-‐arrestins. Science
308, 512-‐517 (2005)
31. Rasmussen, S. G.; Choi, H. J. et al. Crystal structure of the human beta2 adrenergic G-‐
protein-‐coupled receptor. Nature 450, 383-‐387 (2007).
32. Cherezov, V.; Rosenbaum, D. M. et al. High-‐resolution crystal structure of an engineered
human beta2-‐adrenergic G protein-‐coupled receptor. Science 318, 1258-‐1265 (2007).
33. Rosenbaum, D. M.; Cherezov, V. et al. GPCR engineering yields high-‐resolution structural
insights into beta2-‐adrenergic receptor function. Science 318, 1266-‐1273 (2007).
34. Palczewski, K.; Kumasaka, T. et al. Crystal structure of rhodopsin: A G protein-‐coupled
receptor. Science 289, 739-‐745 (2000).
35. Okada, T.; Fujiyoshi, Y. et al. Functional role of internal water molecules in rhodopsin
revealed by X-‐ray crystallography. Proc Natl Acad Sci USA 99, 5982-‐5987. (2002).
36. Katritch, V.; Cherezov, V. et al. Structure-‐function of the g protein-‐coupled receptor
superfamily. Annu Rev Pharmacol Toxicol 53, 531-‐556 (2013).
37. Katritch, V.; Cherezov, V. et al. Diversity and modularity of G protein-‐coupled receptor
structures. Trends Pharmacol Sci 33, 17-‐27 (2012).
38. Rasmussen, S.G.; DeVree, B.T. et al. Crystal structure of the beta2 adrenergic receptor-‐Gs
protein complex. Nature 477, 549-‐555 (2011).
39. Chung, K. Y.; Rasmussen, S. G. et al. Conformational changes in the G protein Gs induced by
the beta2 adrenergic receptor. Nature 477, 611-‐615 (2011).
40. Penela, P., Murga, C. et al. The complex G protein-‐coupled receptor kinase 2 (GRK2)
interactome unveils new physiopathological targets. Br J Pharmacol 160, 821-‐832 (2010).
