J. C. Rodríguez Rey
429
7.
Randle, P.J., Garland, P.B., Hales, C.N., and Newsholme, E.A. 1963. The glucose fatty-‐acid
cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.
Lancet
1:785-‐789.
8.
Hue, L., and Taegtmeyer, H. 2009. The Randle cycle revisited: a new head for an old hat.
Am J Physiol Endocrinol Metab
297:E578-‐591.
9.
Jucker, B.M., Rennings, A.J., Cline, G.W., and Shulman, G.I. 1997. 13C and 31P NMR studies
on the effects of increased plasma free fatty acids on intramuscular glucose metabolism in
the awake rat.
J Biol Chem
272:10464-‐10473.
10.
Saha, A.K., Schwarsin, A.J., Roduit, R., Masse, F., Kaushik, V., Tornheim, K., Prentki, M., and
Ruderman, N.B. 2000. Activation of malonyl-‐CoA decarboxylase in rat skeletal muscle by
contraction and the AMP-‐activated protein kinase activator 5-‐aminoimidazole-‐4-‐
carboxamide-‐1-‐beta -‐D-‐ribofuranoside.
J Biol Chem
275:24279-‐24283.
11.
Riancho, J.A., Vazquez, L., Garcia-‐Perez, M.A., Sainz, J., Olmos, J.M., Hernandez, J.L., Perez-‐
Lopez, J., Amado, J.A., Zarrabeitia, M.T., Cano, A., et al. 2011. Association of ACACB
polymorphisms with obesity and diabetes.
Mol Genet Metab
104:670-‐676.
12.
McGarry, J.D. 2002. Banting lecture 2001: dysregulation of fatty acid metabolism in the
etiology of type 2 diabetes.
Diabetes
51:7-‐18.
13.
Rothman, D.L., Magnusson, I., Cline, G., Gerard, D., Kahn, C.R., Shulman, R.G., and Shulman,
G.I. 1995. Decreased muscle glucose transport/phosphorylation is an early defect in the
pathogenesis of non-‐insulin-‐dependent diabetes mellitus.
Proc Natl Acad Sci U S A
92:983-‐
987.
14.
Rothman, D.L., Shulman, R.G., and Shulman, G.I. 1992. 31P nuclear magnetic resonance
measurements of muscle glucose-‐6-‐phosphate. Evidence for reduced insulin-‐dependent
muscle glucose transport or phosphorylation activity in non-‐insulin-‐dependent diabetes
mellitus.
J Clin Invest
89:1069-‐1075.
15.
Shulman, G.I., Rothman, D.L., Jue, T., Stein, P., DeFronzo, R.A., and Shulman, R.G. 1990.
Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-‐
insulin-‐dependent diabetes by 13C nuclear magnetic resonance spectroscopy.
N Engl J
Med
322:223-‐228.
16.
Brechtel, K., Dahl, D.B., Machann, J., Bachmann, O.P., Wenzel, I., Maier, T., Claussen, C.D.,
Haring, H.U., Jacob, S., and Schick, F. 2001. Fast elevation of the intramyocellular lipid
content in the presence of circulating free fatty acids and hyperinsulinemia: a dynamic 1H-‐
MRS study.
Magn Reson Med
45:179-‐183.
17.
Roden, M., Price, T.B., Perseghin, G., Petersen, K.F., Rothman, D.L., Cline, G.W., and Shulman,
G.I. 1996. Mechanism of free fatty acid-‐induced insulin resistance in humans.
J Clin Invest
97:2859-‐2865.
18.
Cline, G.W., Petersen, K.F., Krssak, M., Shen, J., Hundal, R.S., Trajanoski, Z., Inzucchi, S.,
Dresner, A., Rothman, D.L., and Shulman, G.I. 1999. Impaired glucose transport as a cause
of decreased insulin-‐stimulated muscle glycogen synthesis in type 2 diabetes.
N Engl J Med
341:240-‐246.
19.
McCarthy, M.I. 2010. Genomics, type 2 diabetes, and obesity.
N Engl J Med
363:2339-‐2350.
20.
Watson, R.T., and Pessin, J.E. 2006. Bridging the GAP between insulin signaling and GLUT4
translocation.
Trends Biochem Sci
31:215-‐222.
21.
Watson, R.T., Kanzaki, M., and Pessin, J.E. 2004. Regulated membrane trafficking of the
insulin-‐responsive glucose transporter 4 in adipocytes.
Endocr Rev
25:177-‐204.
22.
Sun, X.J., Rothenberg, P., Kahn, C.R., Backer, J.M., Araki, E., Wilden, P.A., Cahill, D.A.,
Goldstein, B.J., and White, M.F. 1991. Structure of the insulin receptor substrate IRS-‐1
defines a unique signal transduction protein.
Nature
352:73-‐77.
23.
White, M.F. 2002. IRS proteins and the common path to diabetes.
Am J Physiol Endocrinol
Metab
283:E413-‐422.
