An. Real. Acad. Farm. vol 79 nº 3 2013 - page 49

Lípidos y diabetes tipo 2
432
58.
Kim, J.K., Fillmore, J.J., Sunshine, M.J., Albrecht, B., Higashimori, T., Kim, D.W., Liu, Z.X., Soos,
T.J., Cline, G.W., O'Brien, W.R., et al. 2004. PKC-­‐theta knockout mice are protected from fat-­‐
induced insulin resistance.
J Clin Invest
114:823-­‐827.
59.
Gao, Z., Wang, Z., Zhang, X., Butler, A.A., Zuberi, A., Gawronska-­‐Kozak, B., Lefevre, M., York,
D., Ravussin, E., Berthoud, H.R., et al. 2007. Inactivation of PKCtheta leads to increased
susceptibility to obesity and dietary insulin resistance in mice.
Am J Physiol Endocrinol
Metab
292:E84-­‐91.
60.
Raddatz, K., Turner, N., Frangioudakis, G., Liao, B.M., Pedersen, D.J., Cantley, J., Wilks, D.,
Preston, E., Hegarty, B.D., Leitges, M., et al. 2011. Time-­‐dependent effects of Prkce deletion
on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice.
Diabetologia
54:1447-­‐1456.
61.
Boden, G., She, P., Mozzoli, M., Cheung, P., Gumireddy, K., Reddy, P., Xiang, X., Luo, Z., and
Ruderman, N. 2005. Free fatty acids produce insulin resistance and activate the
proinflammatory nuclear factor-­‐kappaB pathway in rat liver.
Diabetes
54:3458-­‐3465.
62.
Shi, H., Kokoeva, M.V., Inouye, K., Tzameli, I., Yin, H., and Flier, J.S. 2006. TLR4 links innate
immunity and fatty acid-­‐induced insulin resistance.
J Clin Invest
116:3015-­‐3025.
63.
Teruel, T., Hernandez, R., and Lorenzo, M. 2001. Ceramide mediates insulin resistance by
tumor necrosis factor-­‐alpha in brown adipocytes by maintaining Akt in an inactive
dephosphorylated state.
Diabetes
50:2563-­‐2571.
64.
Kellerer, M., Coghlan, M., Capp, E., Muhlhofer, A., Kroder, G., Mosthaf, L., Galante, P., Siddle,
K., and Haring, H.U. 1995. Mechanism of insulin receptor kinase inhibition in non-­‐insulin-­‐
dependent diabetes mellitus patients. Phosphorylation of serine 1327 or threonine 1348
is unaltered.
J Clin Invest
96:6-­‐11.
65.
Li, Y., Soos, T.J., Li, X., Wu, J., Degennaro, M., Sun, X., Littman, D.R., Birnbaum, M.J., and
Polakiewicz, R.D. 2004. Protein kinase C Theta inhibits insulin signaling by
phosphorylating IRS1 at Ser(1101).
J Biol Chem
279:45304-­‐45307.
66.
Powell, D.J., Hajduch, E., Kular, G., and Hundal, H.S. 2003. Ceramide disables 3-­‐
phosphoinositide binding to the pleckstrin homology domain of protein kinase B
(PKB)/Akt by a PKCzeta-­‐dependent mechanism.
Mol Cell Biol
23:7794-­‐7808.
67.
Rose, A.J., Vegiopoulos, A., and Herzig, S. 2010. Role of glucocorticoids and the
glucocorticoid receptor in metabolism: insights from genetic manipulations.
J Steroid
Biochem Mol Biol
122:10-­‐20.
68.
Higuchi, N., Kato, M., Shundo, Y., Tajiri, H., Tanaka, M., Yamashita, N., Kohjima, M., Kotoh, K.,
Nakamuta, M., Takayanagi, R., et al. 2008. Liver X receptor in cooperation with SREBP-­‐1c is
a major lipid synthesis regulator in nonalcoholic fatty liver disease.
Hepatol Res
38:1122-­‐
1129.
69.
Moore, D.D. 2012. Nuclear receptors reverse McGarry's vicious cycle to insulin resistance.
Cell Metab
15:615-­‐622.
70.
Lalloyer, F., and Staels, B. 2010. Fibrates, glitazones, and peroxisome proliferator-­‐activated
receptors.
Arterioscler Thromb Vasc Biol
30:894-­‐899.
71.
Lehrke, M., and Lazar, M.A. 2005. The many faces of PPARgamma.
Cell
123:993-­‐999.
72.
Del Bas, J.M., Ricketts, M.L., Baiges, I., Quesada, H., Ardevol, A., Salvado, M.J., Pujadas, G.,
Blay, M., Arola, L., Blade, C., et al. 2008. Dietary procyanidins lower triglyceride levels
signaling through the nuclear receptor small heterodimer partner.
Mol Nutr Food Res
52:1172-­‐1181.
73.
Kim, H.J., Takahashi, M., and Ezaki, O. 1999. Fish oil feeding decreases mature sterol
regulatory element-­‐binding protein 1 (SREBP-­‐1) by down-­‐regulation of SREBP-­‐1c mRNA
in mouse liver. A possible mechanism for down-­‐regulation of lipogenic enzyme mRNAs.
J
Biol Chem
274:25892-­‐25898.
1...,39,40,41,42,43,44,45,46,47,48 50,51,52,53,54,55,56,57,58,59,...132
Powered by FlippingBook